htpX protein (Nitrospira defluvii) - STRING interaction network

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[Homology]

Score

htpX

Probable Protease HtpX; Function of strongly homologous gene; enzyme. (305 aa)

Predicted Functional Partners:

ygdQ

0.664

hflB

0.595

ftsH

0.595

secY

0.558

grpE

0.546

NIDE1237

0.542

btuE

0.534

NIDE1238

0.419

cysNC

0.416

Your Current Organism:

Nitrospira defluvii

NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NIDE1237	NIDE1238	NIDE1237	NIDE1238	Conserved exported protein of unknown function, Cupredoxin family; Homologs of previously reported genes of unknown function; 1324168, 14673090, 6307356, 7592701, 8083153.	Squalene synthase; Function of strongly homologous gene; enzyme.	0.623
NIDE1237	ftsH	NIDE1237	NIDE2929	Conserved exported protein of unknown function, Cupredoxin family; Homologs of previously reported genes of unknown function; 1324168, 14673090, 6307356, 7592701, 8083153.	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.440
NIDE1237	hflB	NIDE1237	NIDE2737	Conserved exported protein of unknown function, Cupredoxin family; Homologs of previously reported genes of unknown function; 1324168, 14673090, 6307356, 7592701, 8083153.	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.440
NIDE1237	htpX	NIDE1237	NIDE1236	Conserved exported protein of unknown function, Cupredoxin family; Homologs of previously reported genes of unknown function; 1324168, 14673090, 6307356, 7592701, 8083153.	Probable Protease HtpX; Function of strongly homologous gene; enzyme.	0.542
NIDE1238	NIDE1237	NIDE1238	NIDE1237	Squalene synthase; Function of strongly homologous gene; enzyme.	Conserved exported protein of unknown function, Cupredoxin family; Homologs of previously reported genes of unknown function; 1324168, 14673090, 6307356, 7592701, 8083153.	0.623
NIDE1238	htpX	NIDE1238	NIDE1236	Squalene synthase; Function of strongly homologous gene; enzyme.	Probable Protease HtpX; Function of strongly homologous gene; enzyme.	0.419
btuE	htpX	NIDE1235	NIDE1236	Predicted Glutathione peroxidase; Function of strongly homologous gene; enzyme; Belongs to the glutathione peroxidase family.	Probable Protease HtpX; Function of strongly homologous gene; enzyme.	0.534
cysNC	htpX	NIDE0411	NIDE1236	Sulfate adenylyltransferase, subunit 1, and adenylylsulfate kinase (bifunctional enzyme); Function of strongly homologous gene; enzyme.	Probable Protease HtpX; Function of strongly homologous gene; enzyme.	0.416
ftsH	NIDE1237	NIDE2929	NIDE1237	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Conserved exported protein of unknown function, Cupredoxin family; Homologs of previously reported genes of unknown function; 1324168, 14673090, 6307356, 7592701, 8083153.	0.440
ftsH	grpE	NIDE2929	NIDE1729	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]	0.418
ftsH	htpX	NIDE2929	NIDE1236	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Probable Protease HtpX; Function of strongly homologous gene; enzyme.	0.595
ftsH	secY	NIDE2929	NIDE1331	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Preprotein translocase, membrane subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.	0.401
grpE	ftsH	NIDE1729	NIDE2929	Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.418
grpE	hflB	NIDE1729	NIDE2737	Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.418
grpE	htpX	NIDE1729	NIDE1236	Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]	Probable Protease HtpX; Function of strongly homologous gene; enzyme.	0.546
hflB	NIDE1237	NIDE2737	NIDE1237	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Conserved exported protein of unknown function, Cupredoxin family; Homologs of previously reported genes of unknown function; 1324168, 14673090, 6307356, 7592701, 8083153.	0.440
hflB	grpE	NIDE2737	NIDE1729	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]	0.418
hflB	htpX	NIDE2737	NIDE1236	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Probable Protease HtpX; Function of strongly homologous gene; enzyme.	0.595
hflB	secY	NIDE2737	NIDE1331	Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Preprotein translocase, membrane subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.	0.401
htpX	NIDE1237	NIDE1236	NIDE1237	Probable Protease HtpX; Function of strongly homologous gene; enzyme.	Conserved exported protein of unknown function, Cupredoxin family; Homologs of previously reported genes of unknown function; 1324168, 14673090, 6307356, 7592701, 8083153.	0.542