guaA protein (Nitrospira defluvii) - STRING interaction network

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Score

guaA

GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (518 aa)

Predicted Functional Partners:

guaB

0.999

argS

0.973

rplJL

0.971

rdgB

0.969

gmk

0.963

rplK

0.960

hpt

0.950

map

0.949

surE

0.948

gatB

0.941

Your Current Organism:

Nitrospira defluvii

NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
argS	guaA	NIDE3290	NIDE1422	Arginyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.973
argS	guaB	NIDE3290	NIDE1421	Arginyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.464
argS	rplJL	NIDE3290	NIDE1302	Arginyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Fused 50S ribosomal proteins L10 and L7/L12 (modular protein); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.787
argS	rplK	NIDE3290	NIDE1300	Arginyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.595
gatB	guaA	NIDE2915	NIDE1422	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.941
gatB	rplJL	NIDE2915	NIDE1302	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	Fused 50S ribosomal proteins L10 and L7/L12 (modular protein); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.638
gatB	rplK	NIDE2915	NIDE1300	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.411
gmk	guaA	NIDE2462	NIDE1422	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.963
gmk	guaB	NIDE2462	NIDE1421	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.467
gmk	hpt	NIDE2462	NIDE2738	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.926
gmk	rplJL	NIDE2462	NIDE1302	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Fused 50S ribosomal proteins L10 and L7/L12 (modular protein); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.484
gmk	surE	NIDE2462	NIDE4107	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.919
guaA	argS	NIDE1422	NIDE3290	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Arginyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.973
guaA	gatB	NIDE1422	NIDE2915	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	0.941
guaA	gmk	NIDE1422	NIDE2462	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.963
guaA	guaB	NIDE1422	NIDE1421	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	hpt	NIDE1422	NIDE2738	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Hypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.950
guaA	map	NIDE1422	NIDE1333	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	0.949
guaA	rdgB	NIDE1422	NIDE1872	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.969
guaA	rplJL	NIDE1422	NIDE1302	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Fused 50S ribosomal proteins L10 and L7/L12 (modular protein); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.971