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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIDE1532Putative Dihydroneopterin aldolase and SAM-dependent methyltransferase (modular protein); Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (309 aa)    
Predicted Functional Partners:
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.973
folE
GTP cyclohydrolase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.947
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
  
 0.940
trpH
Conserved protein of unknown function, PHP family Phosphoesterase; Homologs of previously reported genes of unknown function.
       0.822
NIDE1533
Protein of unknown function; No homology to any previously reported sequences.
       0.601
folC
Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.
  
  
 0.601
rdgB
Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.579
NIDE1530
Protein of unknown function, putative protein kinase; No homology to any previously reported sequences; 10627033, 1239947, 12406230, 1835671, 3291115, 7774814, 8733241, 9044280, 9119030.
  
    0.578
ribD
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.556
NIDE1528
Conserved protein of unknown function, contains FHA domain; Homologs of previously reported genes of unknown function; 11106755, 11911881, 12564991, 7482699.
       0.480
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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