| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIDE1580 | accD | NIDE1580 | NIDE1577 | Conserved exported protein of unknown function, putative LPS-assembly protein Imp; Homologs of previously reported genes of unknown function; 12724388, 16861298, 2547691, 7811102. | Acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.663 |
| NIDE1580 | folC | NIDE1580 | NIDE1579 | Conserved exported protein of unknown function, putative LPS-assembly protein Imp; Homologs of previously reported genes of unknown function; 12724388, 16861298, 2547691, 7811102. | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 0.827 |
| NIDE1580 | recN | NIDE1580 | NIDE1583 | Conserved exported protein of unknown function, putative LPS-assembly protein Imp; Homologs of previously reported genes of unknown function; 12724388, 16861298, 2547691, 7811102. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.538 |
| accD | NIDE1580 | NIDE1577 | NIDE1580 | Acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Conserved exported protein of unknown function, putative LPS-assembly protein Imp; Homologs of previously reported genes of unknown function; 12724388, 16861298, 2547691, 7811102. | 0.663 |
| accD | folC | NIDE1577 | NIDE1579 | Acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 0.780 |
| fhs | folC | NIDE3713 | NIDE1579 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 0.708 |
| fhs | glyA | NIDE3713 | NIDE0168 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
| fhs | guaA | NIDE3713 | NIDE1422 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.791 |
| folC | NIDE1580 | NIDE1579 | NIDE1580 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Conserved exported protein of unknown function, putative LPS-assembly protein Imp; Homologs of previously reported genes of unknown function; 12724388, 16861298, 2547691, 7811102. | 0.827 |
| folC | accD | NIDE1579 | NIDE1577 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.780 |
| folC | fhs | NIDE1579 | NIDE3713 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | 0.708 |
| folC | folE | NIDE1579 | NIDE3555 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.657 |
| folC | folK | NIDE1579 | NIDE0502 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.948 |
| folC | folP | NIDE1579 | NIDE2736 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
| folC | glyA | NIDE1579 | NIDE0168 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.669 |
| folC | guaA | NIDE1579 | NIDE1422 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.652 |
| folC | recN | NIDE1579 | NIDE1583 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.632 |
| folC | valS | NIDE1579 | NIDE1733 | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. | 0.606 |
| folE | folC | NIDE3555 | NIDE1579 | GTP cyclohydrolase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 0.657 |
| folE | folK | NIDE3555 | NIDE0502 | GTP cyclohydrolase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.990 |