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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadCNicotinate-nucleotide diphosphorylase (carboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family. (293 aa)    
Predicted Functional Partners:
nadA
Quinolinate synthetase, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
 
 0.999
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
  
 0.995
sdhA-2
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit or L-aspartate oxidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.967
cinA
CinA-like protein; Function of strongly homologous gene; cell process; Belongs to the CinA family.
    
 0.946
pncB
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
   
 0.938
sdhA
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.936
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
    
 0.926
surE
5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.906
NIDE4241
HAD-like hydrolase, putative purine nucleotidase; Function of strongly homologous gene; enzyme.
     
 0.901
NIDE1731
Putative Biotin-(acetyl-CoA-carboxylase) ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
     
 0.848
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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