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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
npdANAD-dependent deacetylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the sirtuin family. Class III subfamily. (243 aa)    
Predicted Functional Partners:
nadE
NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.945
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.919
pncA
Nicotine deamidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.918
ppnK
NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.915
sthA
Soluble pyridine nucleotide transhydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.909
sthA-2
Soluble pyridine nucleotide transhydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.909
rih
Inosine-uridine preferring nucleoside hydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.901
NIDE3682
Conserved protein of unknown function, TfoX-like; Homologs of previously reported genes of unknown function.
    
   0.767
gdhA
Glutamate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.702
NIDE1738
Putative 2-dehydropantoate 2-reductase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
     0.698
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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