Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NIDE1822Putative Thiamine biosynthesis protein ThiS; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (66 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.964
thiF
Adenylyltransferase ThiF; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.953
moeB
Molybdopterin biosynthesis protein MoeB; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.930
thiS
Thiamine biosynthesis protein ThiS; Function of strongly homologous gene; carrier.
  
  
  0.922
NIDE1815
Homologs of previously reported genes of unknown function; 9605331.
 
 
 0.915
NIDE3395
Putative Thiamine biosynthesis protein ThiS; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
     
  0.900
thiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.833
cysK
Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
    0.821
thiD
Phosphomethylpyrimidine kinase; Function of strongly homologous gene; enzyme.
  
  
 0.805
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.762
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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