STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
clpSATP-dependent Clp protease adapter protein ClpS; Function of strongly homologous gene; regulator; Belongs to the ClpS family. (97 aa)    
Predicted Functional Partners:
clpP
ATP-dependent Clp protease, proteolytic subunit clpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 
 0.896
clpV1
Type VI secretion ATPase, ClpV1 family; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family.
  
 
 0.839
clpB2
Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.839
clpB3
Chaperone protein ClpB; Function of homologous gene experimentally demonstrated in an other organism; factor; Belongs to the ClpA/ClpB family.
  
 
 0.839
clpX
ATP-dependent Clp protease, ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
  
 0.763
trxC
Thioredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier.
      
 0.750
trxA
Thioredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the thioredoxin family.
      
 0.748
trxA-2
Thioredoxin; Function of strongly homologous gene; carrier; Belongs to the thioredoxin family.
      
 0.748
NIDE0563
Radical SAM superfamily protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
     0.727
NIDE1848
Homologs of previously reported genes of unknown function.
  
     0.704
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.