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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIDE1875Probable Peroxiredoxin; Function of strongly homologous gene; enzyme. (211 aa)    
Predicted Functional Partners:
NIDE4034
Putative Thioredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.
  
 0.969
trxB
Thioredoxin-disulfide reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.929
grpE
Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]
   
 
 0.651
fur
Ferric uptake regulation protein; Function of strongly homologous gene; regulator; Belongs to the Fur family.
  
  
 0.630
fur2
Ferric uptake regulation protein Fur; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the Fur family.
  
  
 0.630
perR
Peroxide-responsive repressor PerR; Function of strongly homologous gene; regulator; Belongs to the Fur family.
  
  
 0.630
NIDE0562
Putative Universal stress protein UspA (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
  
  
 0.605
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.563
NIDE1202
Putative Thiol peroxidase (modular protein); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
  
 0.560
NIDE4033
Peroxiredoxin; Function of strongly homologous gene; enzyme.
 
 
 0.556
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.