Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NIDE1895Putative Iron-sulfur cluster assembly protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the HesB/IscA family. (102 aa)    
Predicted Functional Partners:
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      
 0.811
iscU
Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.792
porB
Pyruvate:ferredoxin oxidoreductase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      
 0.785
NIDE1896
Protein of unknown function; No homology to any previously reported sequences.
       0.773
NIDE1897
Protein of unknown function; No homology to any previously reported sequences.
       0.773
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
 
 0.700
hscB
Co-chaperone protein HscB (Hsc20); Function of strongly homologous gene; factor.
  
 
 0.670
radA
DNA recombination protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
      
 0.656
grxD
Glutaredoxin; Function of strongly homologous gene; enzyme.
  
 0.531
NIDE1898
Putative Type I restriction system, N-6 adenine-specific DNA methylase HsdM; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
       0.487
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.