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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
istBInsertion sequence IS21 putative ATP-binding protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (259 aa)    
Predicted Functional Partners:
istA
Transposase for insertion sequence element IS21; Function of strongly homologous gene; enzyme.
  
 0.987
istA-2
Putative Transposase for insertion sequence element IS21; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin.
  
 0.946
NIDE0583
Conserved membrane protein of unknown function, UPF0114; Homologs of previously reported genes of unknown function.
 
      0.897
dnaB
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
  
 
 0.828
dnaB-2
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
  
 
 0.828
NIDE2837
Putative Transposase for insertion sequence element IS21; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin.
  
 0.808
NIDE2138
Putative Transposase for insertion sequence element IS21; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin.
  
 0.801
rpsL
30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
      
 0.537
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.474
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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