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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIDE2038Conserved protein of unknown function, putative AAA-5 ATPase; Homologs of previously reported genes of unknown function; 9927482. (317 aa)    
Predicted Functional Partners:
NIDE2037
Homologs of previously reported genes of unknown function.
 
     0.950
ligA
DNA ligase (NAD(+)); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
  
    0.787
NIDE0343
Conserved protein of unknown function, DUF58; Homologs of previously reported genes of unknown function.
 
  
 0.514
NIDE4176
Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
    0.475
NIDE2039
Exported protein of unknown function, contains LysM domain; No homology to any previously reported sequences; 1352512, 1593644, 3622514.
       0.460
NIDE1185
Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.453
NIDE3564
Protein of unknown function, contains von Willebrand factor; No homology to any previously reported sequences; 8440408, 9759493.
  
  
 0.434
trpE
Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
       0.428
NIDE0254
Peptidase M24; Function of strongly homologous gene; enzyme.
  
     0.410
NIDE0577
Homologs of previously reported genes of unknown function.
  
     0.404
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.