Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
NIDE2038Conserved protein of unknown function, putative AAA-5 ATPase; Homologs of previously reported genes of unknown function; 9927482. (317 aa)    
Predicted Functional Partners:
NIDE2037
Homologs of previously reported genes of unknown function.
 
     0.949
NIDE3564
Protein of unknown function, contains von Willebrand factor; No homology to any previously reported sequences; 8440408, 9759493.
  
 
 0.818
ligA
DNA ligase (NAD(+)); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
  
    0.783
NIDE0343
Conserved protein of unknown function, DUF58; Homologs of previously reported genes of unknown function.
 
  
 0.519
NIDE4176
Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
    0.480
NIDE2039
Exported protein of unknown function, contains LysM domain; No homology to any previously reported sequences; 1352512, 1593644, 3622514.
       0.460
NIDE1185
Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
   
 0.458
trpE
Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
       0.428
NIDE0254
Peptidase M24; Function of strongly homologous gene; enzyme.
  
   
 0.415
NIDE0577
Homologs of previously reported genes of unknown function.
  
     0.404
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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