Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
top6ADNA topoisomerase VI, subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (368 aa)    
Predicted Functional Partners:
top6B
DNA topoisomerase VI, subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
 
 
 0.993
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.835
NIDE1906
Putative Metallophosphoesterase, possible DNA repair exonuclease SbcCD, subunit D; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
 0.813
NIDE3177
Protein of unknown function, contains DnaJ domain; No homology to any previously reported sequences; 12454054, 15170475, 8016869, 9644977.
    
 
 0.780
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.709
pheT
Phenylalanyl-tRNA synthetase, beta subunit; Function of strongly homologous gene; enzyme.
  
    0.659
pheS
Phenylalanyl-tRNA synthetase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
  
     0.589
NIDE2075
Protein of unknown function; No homology to any previously reported sequences.
       0.566
NIDE2076
Exported protein of unknown function; No homology to any previously reported sequences.
       0.526
NIDE2997
Putative UDP-glucose 4-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
     0.441
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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