Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NIDE2086Conserved protein of unknown function, putative ATP-dependent nuclease, subunit A; Homologs of previously reported genes of unknown function; 3537960, 9288744, 9571036; Belongs to the helicase family. UvrD subfamily. (1128 aa)    
Predicted Functional Partners:
NIDE2085
Conserved protein of unknown function, putative ATP-dependent nuclease, subunit B; Homologs of previously reported genes of unknown function.
 
 
 0.998
NIDE2087
Exported protein of unknown function, TPR-like; No homology to any previously reported sequences.
       0.772
NIDE2084
Putative Thioredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.
       0.516
dnaE
DNA polymerase III, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.510
dnaE2
DNA polymerase III, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.502
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.492
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.478
ada
Methylated-DNA-[protein]-cysteine S-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.476
NIDE1906
Putative Metallophosphoesterase, possible DNA repair exonuclease SbcCD, subunit D; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.464
NIDE1291
ATP-dependent DNA helicase; Function of strongly homologous gene; enzyme.
 
   
0.453
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.