STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobA/hemDUroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. (489 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
NIDE2764
Putative Precorrin-2 dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 0.999
hemB
Delta-aminolevulinic acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family.
 
 
 0.992
cobI
Precorrin-2 C(20)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family.
 
 
 0.984
cbiX
Sirohydrochlorin cobaltochelatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.968
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.963
cbiG
Cobalamin biosynthesis protein CbiG; Function of strongly homologous gene; enzyme.
 
   
 0.956
hemD
Porphyrin biosynthesis protein HemD; Function of strongly homologous gene; enzyme.
 
 
0.956
NIDE0407
Putative Sulfite reductase, contains SirA-like domain (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.949
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.948
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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