close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIDE2199Conserved protein of unknown function, contains HD domain; Homologs of previously reported genes of unknown function. (532 aa)    
Predicted Functional Partners:
NIDE2200
Protein of unknown function; No homology to any previously reported sequences.
       0.796
NIDE4156
Protein of unknown function, contains Diguanylate kinase domain; No homology to any previously reported sequences; 11682196, 15063857, 15306016, 15569936, 15716451.
  
 
 0.735
NIDE2522
Sensory response regulator with diguanylate cyclase domain; Function of strongly homologous gene; regulator.
 
   
 0.728
NIDE2310
Protein of unknown function, contains Diguanylate cyclase domain; No homology to any previously reported sequences; 11682196, 15063857, 15075296, 15306016, 15569936, 15716451, 16418169, 17010156, 7592388.
  
 
 0.692
NIDE1584
Putative Response regulator with HD domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
 
    0.661
NIDE0390
Putative Signal transduction response regulator, receiver and diguanylate cyclase domain (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
 
   
 0.655
NIDE2201
Conserved protein of unknown function, putative Lipolytic enzyme; Homologs of previously reported genes of unknown function.
       0.592
trxA-2
Thioredoxin; Function of strongly homologous gene; carrier; Belongs to the thioredoxin family.
       0.581
NIDE4197
Putative CheY-like response regulator modulated diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
  
   
 0.532
NIDE0805
Putative Hybrid histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.462
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
Server load: low (26%) [HD]