STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trxA-2Thioredoxin; Function of strongly homologous gene; carrier; Belongs to the thioredoxin family. (104 aa)    
Predicted Functional Partners:
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.826
NIDE2201
Conserved protein of unknown function, putative Lipolytic enzyme; Homologs of previously reported genes of unknown function.
  
    0.820
trxB
Thioredoxin-disulfide reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.812
perR
Peroxide-responsive repressor PerR; Function of strongly homologous gene; regulator; Belongs to the Fur family.
  
 
 0.804
NIDE2447
Putative Arsenate reductase (glutaredoxin); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the ArsC family.
   
  
 0.788
nrdJ
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.772
bcp
Peroxiredoxin; Function of strongly homologous gene; enzyme.
  
 
 0.766
clpS
ATP-dependent Clp protease adapter protein ClpS; Function of strongly homologous gene; regulator; Belongs to the ClpS family.
      
 0.748
NIDE2200
Protein of unknown function; No homology to any previously reported sequences.
  
    0.594
clpP
ATP-dependent Clp protease, proteolytic subunit clpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 
 0.565
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.