Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NIDE2242Homologs of previously reported genes of unknown function. (355 aa)    
Predicted Functional Partners:
NIDE2243
Protein of unknown function; No homology to any previously reported sequences.
       0.773
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
   
  
 0.647
NIDE4176
Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.640
NIDE0206
Protein of unknown function, CbiX domain; No homology to any previously reported sequences; 11215515, 12055304, 12686546, 12869542, 16042605, 16835730.
  
  
 0.638
hemY
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
     
 0.636
NIDE2245
Membrane protein of unknown function, putative 4Fe-4S ferredoxin; No homology to any previously reported sequences; 2600971, 3932661.
 
  
 0.531
NIDE0561
Radical SAM superfamily protein, putative Coenzyme PQQ synthesis protein E; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
   
0.475
hemD
Porphyrin biosynthesis protein HemD; Function of strongly homologous gene; enzyme.
 
  
 0.467
cobA/hemD
Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family.
 
  
 0.462
exbD
Biopolymer transport protein exbD; Function of strongly homologous gene; transporter.
      
 0.424
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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