Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NIDE2453Heat shock protein, Hsp20 family; Function of strongly homologous gene; factor; Belongs to the small heat shock protein (HSP20) family. (151 aa)    
Predicted Functional Partners:
clpV1
Type VI secretion ATPase, ClpV1 family; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family.
  
 
 0.768
clpB2
Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.768
clpB3
Chaperone protein ClpB; Function of homologous gene experimentally demonstrated in an other organism; factor; Belongs to the ClpA/ClpB family.
  
 
 0.768
glnA
Glutamine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 
 0.721
hslV
Heat shock protein HslUV, peptidase component; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
   
  
 0.581
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.547
hscA
Chaperone protein HscA (Hsc66); Function of homologous gene experimentally demonstrated in an other organism; factor; Belongs to the heat shock protein 70 family.
  
 
 0.547
grpE
Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]
  
 
 0.531
yjeF
Conserved protein of unknown function, putative Carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydr [...]
 
  
 0.503
NIDE2452
Protein of unknown function; No homology to any previously reported sequences.
       0.501
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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