| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIDE1755 | NIDE3847 | NIDE1755 | NIDE3847 | Conserved protein of unknown function, putative Exodeoxyribonuclease; Homologs of previously reported genes of unknown function; 10838565, 1748997, 7885481. | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.702 |
| NIDE1755 | nth | NIDE1755 | NIDE2460 | Conserved protein of unknown function, putative Exodeoxyribonuclease; Homologs of previously reported genes of unknown function; 10838565, 1748997, 7885481. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.772 |
| NIDE1755 | nth-2 | NIDE1755 | NIDE4162 | Conserved protein of unknown function, putative Exodeoxyribonuclease; Homologs of previously reported genes of unknown function; 10838565, 1748997, 7885481. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.772 |
| NIDE3847 | NIDE1755 | NIDE3847 | NIDE1755 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved protein of unknown function, putative Exodeoxyribonuclease; Homologs of previously reported genes of unknown function; 10838565, 1748997, 7885481. | 0.702 |
| NIDE3847 | mutT | NIDE3847 | NIDE1915 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Mutator MutT protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.712 |
| NIDE3847 | nth | NIDE3847 | NIDE2460 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.826 |
| NIDE3847 | nth-2 | NIDE3847 | NIDE4162 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.826 |
| NIDE3847 | xthA | NIDE3847 | NIDE4335 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Exodeoxyribonuclease III; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.702 |
| coaBC | gmk | NIDE2464 | NIDE2462 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.912 |
| coaBC | hflX | NIDE2464 | NIDE2459 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Putative GTPase HflX, GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.590 |
| coaBC | nth | NIDE2464 | NIDE2460 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.648 |
| coaBC | rpoZ | NIDE2464 | NIDE2463 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | DNA-directed RNA polymerase, omega subunit (modular protein); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.844 |
| coaBC | yicC | NIDE2464 | NIDE2461 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Homologs of previously reported genes of unknown function. | 0.653 |
| gmk | coaBC | NIDE2462 | NIDE2464 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.912 |
| gmk | hflX | NIDE2462 | NIDE2459 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Putative GTPase HflX, GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.637 |
| gmk | nth | NIDE2462 | NIDE2460 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.655 |
| gmk | rpoZ | NIDE2462 | NIDE2463 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | DNA-directed RNA polymerase, omega subunit (modular protein); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.962 |
| gmk | yicC | NIDE2462 | NIDE2461 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Homologs of previously reported genes of unknown function. | 0.903 |
| hflX | coaBC | NIDE2459 | NIDE2464 | Putative GTPase HflX, GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.590 |
| hflX | gmk | NIDE2459 | NIDE2462 | Putative GTPase HflX, GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.637 |
STRING v12.5 is now available!
