node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
kdsA | kdsB | NIDE2556 | NIDE2554 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.916 |
kdsA | kdsC | NIDE2556 | NIDE2985 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.998 |
kdsA | kdsD | NIDE2556 | NIDE2557 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | Arabinose-5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.997 |
kdsA | lepA | NIDE2556 | NIDE2551 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.521 |
kdsA | lepB | NIDE2556 | NIDE2552 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | Signal peptidase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase S26 family. | 0.513 |
kdsA | lpxB | NIDE2556 | NIDE3037 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | Lipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.742 |
kdsA | lpxK | NIDE2556 | NIDE3032 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.822 |
kdsA | pyrG | NIDE2556 | NIDE2555 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.645 |
kdsA | rfaEa | NIDE2556 | NIDE2553 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | D-beta-D-heptose 7-phosphate kinase, domain I of bifunctional protein HldE; Function of strongly homologous gene; enzyme. | 0.584 |
kdsA | waaA | NIDE2556 | NIDE3033 | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.813 |
kdsB | kdsA | NIDE2554 | NIDE2556 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | 0.916 |
kdsB | kdsC | NIDE2554 | NIDE2985 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.997 |
kdsB | kdsD | NIDE2554 | NIDE2557 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Arabinose-5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.940 |
kdsB | lepA | NIDE2554 | NIDE2551 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.827 |
kdsB | lepB | NIDE2554 | NIDE2552 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Signal peptidase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase S26 family. | 0.827 |
kdsB | lpxB | NIDE2554 | NIDE3037 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Lipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.800 |
kdsB | lpxK | NIDE2554 | NIDE3032 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.834 |
kdsB | pyrG | NIDE2554 | NIDE2555 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.816 |
kdsB | rfaEa | NIDE2554 | NIDE2553 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | D-beta-D-heptose 7-phosphate kinase, domain I of bifunctional protein HldE; Function of strongly homologous gene; enzyme. | 0.852 |
kdsB | waaA | NIDE2554 | NIDE3033 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.982 |