Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NIDE2720Protein of unknown function; No homology to any previously reported sequences; 16894158. (669 aa)    
Predicted Functional Partners:
secA-2
Protein translocase, subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
     
 0.637
NIDE2719
Putative Secretion protein HlyD family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
     
 0.626
NIDE2721
Putative Secretion protein HlyD family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
       0.590
ftsK
DNA translocase FtsK; Function of strongly homologous gene; enzyme.
  
 
 0.525
secY
Preprotein translocase, membrane subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
    
 
 0.501
NIDE0925
Conserved protein of unknown function, putative Protein kinase; Homologs of previously reported genes of unknown function.
  
 
 0.490
NIDE2723
Peptidase, M50 family; Function of strongly homologous gene; enzyme.
     
 0.456
ftsW
Cell division protein FtsW; Function of homologous gene experimentally demonstrated in an other organism; cell process; Belongs to the SEDS family.
   
   0.452
mrdB
Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
   
   0.452
NIDE2724
Conserved protein of unknown function, contains GAF domain; Homologs of previously reported genes of unknown function; 12271124, 15708973, 9433123.
     
 0.447
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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