node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NIDE4176 | cobA/hemD | NIDE4176 | NIDE2103 | Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | 0.926 |
NIDE4176 | hemB | NIDE4176 | NIDE2741 | Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Delta-aminolevulinic acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. | 0.748 |
NIDE4176 | hemC | NIDE4176 | NIDE2744 | Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.977 |
NIDE4176 | hemD | NIDE4176 | NIDE2743 | Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Porphyrin biosynthesis protein HemD; Function of strongly homologous gene; enzyme. | 0.920 |
NIDE4176 | hemE | NIDE4176 | NIDE1215 | Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.994 |
cobA/hemD | NIDE4176 | NIDE2103 | NIDE4176 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Putative Uroporphyrinogen III synthase HemD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.926 |
cobA/hemD | cobM | NIDE2103 | NIDE2102 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.906 |
cobA/hemD | cobQ | NIDE2103 | NIDE2659 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.788 |
cobA/hemD | hemA | NIDE2103 | NIDE2745 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.959 |
cobA/hemD | hemB | NIDE2103 | NIDE2741 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Delta-aminolevulinic acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. | 0.996 |
cobA/hemD | hemC | NIDE2103 | NIDE2744 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
cobA/hemD | hemD | NIDE2103 | NIDE2743 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Porphyrin biosynthesis protein HemD; Function of strongly homologous gene; enzyme. | 0.958 |
cobA/hemD | hemE | NIDE2103 | NIDE1215 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.948 |
cobA/hemD | hemL | NIDE2103 | NIDE4293 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Glutamate-1-semialdehyde-2,1-aminomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.926 |
cobA/hemD | ribF | NIDE2103 | NIDE2740 | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | Riboflavin biosynthesis protein RibF; Function of strongly homologous gene; enzyme; Belongs to the ribF family. | 0.483 |
cobM | cobA/hemD | NIDE2102 | NIDE2103 | Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family. | 0.906 |
cobM | cobQ | NIDE2102 | NIDE2659 | Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.974 |
cobM | hemA | NIDE2102 | NIDE2745 | Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.796 |
cobM | hemB | NIDE2102 | NIDE2741 | Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Delta-aminolevulinic acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. | 0.816 |
cobM | hemC | NIDE2102 | NIDE2744 | Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.928 |