Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (468 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.999
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.996
hemD
Porphyrin biosynthesis protein HemD; Function of strongly homologous gene; enzyme.
 
  
 0.991
hemB
Delta-aminolevulinic acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family.
 
  
 0.972
gltX
Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
   
 
 0.966
cobA/hemD
Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family.
 
  
 0.963
NIDE2746
Putative Cytochrome c biogenesis protein CcsA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
 
     0.887
cobM
Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
   
 0.817
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
     
 0.810
cobJ
Precorrin-3B C(17)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.786
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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