| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIDE2908 | era | NIDE2908 | NIDE2911 | Homologs of previously reported genes of unknown function. | GTP-binding protein Era homolog; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | 0.481 |
| NIDE2908 | recO | NIDE2908 | NIDE2909 | Homologs of previously reported genes of unknown function. | Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.717 |
| era | NIDE2908 | NIDE2911 | NIDE2908 | GTP-binding protein Era homolog; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Homologs of previously reported genes of unknown function. | 0.481 |
| era | pdxJ | NIDE2911 | NIDE4117 | GTP-binding protein Era homolog; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.715 |
| era | phoL | NIDE2911 | NIDE4089 | GTP-binding protein Era homolog; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | PhoH-like protein; Function of strongly homologous gene; putative enzyme. | 0.618 |
| era | recO | NIDE2911 | NIDE2909 | GTP-binding protein Era homolog; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.761 |
| holA | radA | NIDE4236 | NIDE1676 | Putative DNA polymerase III, delta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA recombination protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.804 |
| holA | recO | NIDE4236 | NIDE2909 | Putative DNA polymerase III, delta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.784 |
| holA | recR | NIDE4236 | NIDE0280 | Putative DNA polymerase III, delta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Recombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.433 |
| holA | ruvA | NIDE4236 | NIDE0416 | Putative DNA polymerase III, delta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.792 |
| maeA2 | recO | NIDE3846 | NIDE2909 | NAD-dependent malic enzyme; Function of strongly homologous gene; enzyme. | Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.800 |
| pdxJ | era | NIDE4117 | NIDE2911 | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | GTP-binding protein Era homolog; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | 0.715 |
| pdxJ | recO | NIDE4117 | NIDE2909 | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.825 |
| pdxJ | recR | NIDE4117 | NIDE0280 | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | Recombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.836 |
| phoL | era | NIDE4089 | NIDE2911 | PhoH-like protein; Function of strongly homologous gene; putative enzyme. | GTP-binding protein Era homolog; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | 0.618 |
| phoL | recO | NIDE4089 | NIDE2909 | PhoH-like protein; Function of strongly homologous gene; putative enzyme. | Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.853 |
| radA | holA | NIDE1676 | NIDE4236 | DNA recombination protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | Putative DNA polymerase III, delta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.804 |
| radA | recJ | NIDE1676 | NIDE3264 | DNA recombination protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | Single-stranded-DNA-specific exonuclease RecJ; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.507 |
| radA | recO | NIDE1676 | NIDE2909 | DNA recombination protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.737 |
| radA | ruvA | NIDE1676 | NIDE0416 | DNA recombination protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.799 |
