Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
manB/pgmBifunctional Phosphoglucomutase/Phosphomannomutase; Function of strongly homologous gene; enzyme. (466 aa)    
Predicted Functional Partners:
manC/pmi
Bifunctional Mannose-1-phosphate guanylyltransferase/Mannose-6-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 0.996
galU
UTP--glucose-1-phosphate uridylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.980
NIDE3388
Putative Nucleotidyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 0.956
pgm
Phosphoglucomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
0.950
NIDE3903
Alpha-glucan phosphorylase; Function of strongly homologous gene; enzyme.
 
 
 0.942
glgP
Glycogen phosphorylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.941
NIDE3821
Putative Mannose-1-phosphate guanylyltransferase (GDP); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 
 0.937
rfbF
Glucose-1-phosphate cytidylyltransferase; Function of strongly homologous gene; enzyme.
  
 
 0.930
glgC
Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
  
 
 0.926
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.924
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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