| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aclA | acsA | NIDE0835 | NIDE1643 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.826 |
| aclA | acsA-2 | NIDE0835 | NIDE3851 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Acetyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.826 |
| aclA | atoB | NIDE0835 | NIDE3116 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. | 0.924 |
| aclA | fadA | NIDE0835 | NIDE3104 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 3-ketoacyl-CoA thiolase; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. | 0.924 |
| aclA | gltA | NIDE0835 | NIDE2451 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. | 0.955 |
| aclA | prpB | NIDE0835 | NIDE3126 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. | 0.833 |
| aclA | prpC | NIDE0835 | NIDE3127 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2-methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. | 0.570 |
| aclA | prpD | NIDE0835 | NIDE3125 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2-methylcitrate dehydratase; Function of strongly homologous gene; enzyme. | 0.817 |
| aclA | sucC | NIDE0835 | NIDE0840 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.999 |
| aclA | sucD | NIDE0835 | NIDE0841 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Succinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.722 |
| acsA | aclA | NIDE1643 | NIDE0835 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.826 |
| acsA | acsA-2 | NIDE1643 | NIDE3851 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Acetyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.910 |
| acsA | atoB | NIDE1643 | NIDE3116 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. | 0.984 |
| acsA | fadA | NIDE1643 | NIDE3104 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 3-ketoacyl-CoA thiolase; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. | 0.984 |
| acsA | gltA | NIDE1643 | NIDE2451 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. | 0.964 |
| acsA | prpB | NIDE1643 | NIDE3126 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. | 0.890 |
| acsA | prpC | NIDE1643 | NIDE3127 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 2-methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. | 0.964 |
| acsA | prpD | NIDE1643 | NIDE3125 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 2-methylcitrate dehydratase; Function of strongly homologous gene; enzyme. | 0.550 |
| acsA | sucC | NIDE1643 | NIDE0840 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.829 |
| acsA | sucD | NIDE1643 | NIDE0841 | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Succinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.830 |
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