| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIDE1252 | NIDE3217 | NIDE1252 | NIDE3217 | Homologs of previously reported genes of unknown function. | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | 0.442 |
| NIDE3217 | NIDE1252 | NIDE3217 | NIDE1252 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | Homologs of previously reported genes of unknown function. | 0.442 |
| NIDE3217 | NIDE3218 | NIDE3217 | NIDE3218 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | Putative N-carbamoyl-D-amino acid hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.606 |
| NIDE3217 | NIDE4034 | NIDE3217 | NIDE4034 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | Putative Thioredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. | 0.697 |
| NIDE3217 | dnaN | NIDE3217 | NIDE0002 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.748 |
| NIDE3217 | gyrB | NIDE3217 | NIDE0003 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.477 |
| NIDE3217 | hflC | NIDE3217 | NIDE3712 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | FtsH protease activity modulator HflC; HflC and HflK could regulate a protease. | 0.442 |
| NIDE3217 | hflK | NIDE3217 | NIDE3711 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | FtsH protease activity modulator HflK; HflC and HflK could encode or regulate a protease. | 0.442 |
| NIDE3217 | nrdJ | NIDE3217 | NIDE1937 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.990 |
| NIDE3217 | polA | NIDE3217 | NIDE4158 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.510 |
| NIDE3217 | yqgF | NIDE3217 | NIDE1708 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | Predicted Holliday junction resolvase (modular protein); Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.796 |
| NIDE3218 | NIDE3217 | NIDE3218 | NIDE3217 | Putative N-carbamoyl-D-amino acid hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | 0.606 |
| NIDE4034 | NIDE3217 | NIDE4034 | NIDE3217 | Putative Thioredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | 0.697 |
| NIDE4034 | nrdJ | NIDE4034 | NIDE1937 | Putative Thioredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.818 |
| NIDE4034 | polA | NIDE4034 | NIDE4158 | Putative Thioredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.403 |
| dnaN | NIDE3217 | NIDE0002 | NIDE3217 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | 0.748 |
| dnaN | gyrB | NIDE0002 | NIDE0003 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.972 |
| dnaN | nrdJ | NIDE0002 | NIDE1937 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.825 |
| dnaN | polA | NIDE0002 | NIDE4158 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.996 |
| gyrB | NIDE3217 | NIDE0003 | NIDE3217 | DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | 0.477 |
STRING v12.5 is now available!
