| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIDE2230 | osmC | NIDE2230 | NIDE0044 | Homologs of previously reported genes of unknown function. | Peroxiredoxin; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.441 |
| NIDE2230 | wrbA | NIDE2230 | NIDE3258 | Homologs of previously reported genes of unknown function. | NAD(P)H:quinone oxidoreductase WrbA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.567 |
| NIDE3260 | wrbA | NIDE3260 | NIDE3258 | Protein of unknown function; No homology to any previously reported sequences. | NAD(P)H:quinone oxidoreductase WrbA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.596 |
| acnA | mscL | NIDE0836 | NIDE0267 | Aconitate hydratase; Function of strongly homologous gene; enzyme. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.589 |
| acnA | mutL | NIDE0836 | NIDE3356 | Aconitate hydratase; Function of strongly homologous gene; enzyme. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.668 |
| acnA | osmC | NIDE0836 | NIDE0044 | Aconitate hydratase; Function of strongly homologous gene; enzyme. | Peroxiredoxin; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.736 |
| acnA | wrbA | NIDE0836 | NIDE3258 | Aconitate hydratase; Function of strongly homologous gene; enzyme. | NAD(P)H:quinone oxidoreductase WrbA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.694 |
| dnaK | grpE | NIDE1728 | NIDE1729 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.996 |
| dnaK | osmC | NIDE1728 | NIDE0044 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Peroxiredoxin; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.559 |
| dnaK | wrbA | NIDE1728 | NIDE3258 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | NAD(P)H:quinone oxidoreductase WrbA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.564 |
| grpE | dnaK | NIDE1729 | NIDE1728 | Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.996 |
| grpE | mscL | NIDE1729 | NIDE0267 | Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.735 |
| grpE | mutL | NIDE1729 | NIDE3356 | Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.721 |
| grpE | osmC | NIDE1729 | NIDE0044 | Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | Peroxiredoxin; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.737 |
| grpE | trxB | NIDE1729 | NIDE1127 | Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | Thioredoxin-disulfide reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.765 |
| grpE | wrbA | NIDE1729 | NIDE3258 | Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | NAD(P)H:quinone oxidoreductase WrbA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.719 |
| mscL | acnA | NIDE0267 | NIDE0836 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Aconitate hydratase; Function of strongly homologous gene; enzyme. | 0.589 |
| mscL | grpE | NIDE0267 | NIDE1729 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.735 |
| mscL | mutL | NIDE0267 | NIDE3356 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.701 |
| mscL | osmC | NIDE0267 | NIDE0044 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Peroxiredoxin; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.696 |
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