Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NIDE3334Protein of unknown function; No homology to any previously reported sequences. (224 aa)    
Predicted Functional Partners:
rpsL
30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
   
 0.726
NIDE3335
Putative ABC-2 type transport system, ATP-binding and permease component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
       0.664
NIDE3336
Membrane protein of unknown function; No homology to any previously reported sequences.
       0.664
tufA
Elongation factor Tu (EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
   0.581
tufB
Elongation factor Tu (EF-Tu); Function of homologous gene experimentally demonstrated in an other organism; factor.
   
   0.581
NIDE3338
ABC-type transport system, ATP-binding component; Function of strongly homologous gene; transporter.
       0.546
NIDE3339
Putative Cytochrome c-type protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.
       0.511
mobB
Molybdopterin-guanine dinucleotide biosynthesis protein B; Function of homologous gene experimentally demonstrated in an other organism; factor.
       0.511
pyrG
CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
   
    0.489
moeA
Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
       0.478
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.