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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sgaASerine-glyoxylate transaminase; Function of strongly homologous gene; enzyme. (381 aa)    
Predicted Functional Partners:
serA
D-3-phosphoglycerate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.906
hisZ
ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
       0.680
dnaB
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
       0.666
thrH
Homoserine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.586
alaS
Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
  
 0.568
purD
Phosphoribosylamine-glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family.
  
    0.568
gltB
Glutamate synthase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 0.510
NIDE4164
Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.505
NIDE3445
Putative Lytic murein transglycosylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
       0.486
NIDE3330
Conserved protein of unknown function, SDR family; Homologs of previously reported genes of unknown function; 7742302.
  
 0.483
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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