Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mdtBMultidrug efflux system, subunit B; Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1037 aa)    
Predicted Functional Partners:
mdtA
Multidrug efflux system, subunit A; Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
   0.968
ksgA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
      
 0.799
mdtC
Multidrug efflux system, subunit C; Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
    
0.791
NIDE3530
Protein of unknown function; No homology to any previously reported sequences.
       0.773
NIDE1686
Putative Membrane-fusion protein of multidrug efflux transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.664
NIDE3531
Transcriptional regulator, LysR family; Function of strongly homologous gene; regulator; Belongs to the LysR transcriptional regulatory family.
       0.664
ttgC
RND efflux system, outer membrane factor lipoprotein; Function of strongly homologous gene; transporter.
 
   0.648
oprM
RND efflux system, outer membrane factor lipoprotein; Function of strongly homologous gene; transporter.
 
   0.631
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
      
 0.627
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
   
  
 0.627
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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