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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
erpA2Iron-sulfur cluster insertion protein ErpA; Function of homologous gene experimentally demonstrated in an other organism; factor; Belongs to the HesB/IscA family. (106 aa)    
Predicted Functional Partners:
pts
6-pyruvoyl-tetrahydropterin synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
       0.782
folE
GTP cyclohydrolase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.779
NIDE3557
Protein of unknown function; No homology to any previously reported sequences.
       0.773
iscU
Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
  
 0.751
fdx
2Fe-2S ferredoxin; Function of strongly homologous gene; carrier.
  
 
 0.726
nuoE
NADH-quinone oxidoreductase, subunit E; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
  
 0.705
nuoM
NADH-quinone oxidoreductase, membrane subunit M; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      
 0.704
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
  
 0.692
nuoH
NADH-quinone oxidoreductase, membrane subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
      
 0.687
nuoL
NADH-quinone oxidoreductase, membrane subunit L; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      
 0.671
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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