Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hflCFtsH protease activity modulator HflC; HflC and HflK could regulate a protease. (286 aa)    
Predicted Functional Partners:
hflK
FtsH protease activity modulator HflK; HflC and HflK could encode or regulate a protease.
   
 0.997
fdsA
Formate dehydrogenase, alpha subunit; Function of strongly homologous gene; enzyme.
      
 0.793
degP
Serine protease Do; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.764
degP-2
Protease Do; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.764
hslV
Heat shock protein HslUV, peptidase component; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
   
  
 0.760
nuoCD
NADH-quinone oxidoreductase, subunits C and D; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
 
 0.752
hflB
Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.709
ftsH
Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.709
fhs
Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family.
    
 
 0.641
NIDE0132
Homologs of previously reported genes of unknown function; 9714164, 9857196.
  
  
 0.602
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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