Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
trxCThioredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier. (144 aa)    
Predicted Functional Partners:
NIDE2447
Putative Arsenate reductase (glutaredoxin); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the ArsC family.
   
  
 0.816
trxB
Thioredoxin-disulfide reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.812
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.802
nrdJ
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.772
clpS
ATP-dependent Clp protease adapter protein ClpS; Function of strongly homologous gene; regulator; Belongs to the ClpS family.
      
 0.750
clpP
ATP-dependent Clp protease, proteolytic subunit clpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 
 0.711
NIDE3879
Putative Cytochrome c (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.
     
 0.681
NIDE3880
Conserved protein of unknown function, putative Polyphosphate kinase; Homologs of previously reported genes of unknown function; 12486232.
       0.668
gltB
Glutamate synthase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.562
clpX
ATP-dependent Clp protease, ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
  
  
 0.533
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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