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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhB-2Dehydrogenase (E1) component of pyruvate dehydrogenase complex, beta subunit (Transketolase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)    
Predicted Functional Partners:
NIDE3113
Putative 2-oxoisovalerate dehydrogenase, alpha subunit (TPP-binding module); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.999
pdhA
Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.999
pdhA-2
Dehydrogenase (E1) component of pyruvate dehydrogenase complex, alpha subunit (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.999
pdhC
Dihydrolipoamide acetyltransferase (E2) component of pyruvate dehydrogenase complex; Function of strongly homologous gene; enzyme.
 0.997
NIDE3115
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.990
NIDE3854
Putative Pyruvate dehydrogenase complex, dihydrolipoamide acetyltransferase (E2) component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.990
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.953
lpd
Dihydrolipoyl dehydrogenase, E3 component of Pyruvate and 2-oxoglutarate dehydrogenase complexes; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.898
NIDE4341
Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.803
NIDE1146
Putative Mercuric reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 0.773
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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