STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
iscAIron-sulfur cluster assembly protein IscA; Function of homologous gene experimentally demonstrated in an other organism; factor; Belongs to the HesB/IscA family. (119 aa)    
Predicted Functional Partners:
iscU
Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.946
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
 
 0.909
hscB
Co-chaperone protein HscB (Hsc20); Function of strongly homologous gene; factor.
 
 
 0.874
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      
 0.811
porB
Pyruvate:ferredoxin oxidoreductase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      
 0.785
NIDE4023
Putative Transcription factor IscR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
  
  
 0.725
hscA
Chaperone protein HscA (Hsc66); Function of homologous gene experimentally demonstrated in an other organism; factor; Belongs to the heat shock protein 70 family.
 
 
 0.717
fdxB
2Fe-2S ferredoxin; Function of strongly homologous gene; carrier.
 
 0.713
grxD
Glutaredoxin; Function of strongly homologous gene; enzyme.
 
 0.664
radA
DNA recombination protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
      
 0.656
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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