Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NIDE4038Putative 6-pyruvoyl-tetrahydropterin synthase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (250 aa)    
Predicted Functional Partners:
queE
Putative Radical-activating enzyme, radical SAM superfamily; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.985
folE
GTP cyclohydrolase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.949
pts
6-pyruvoyl-tetrahydropterin synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 
0.915
queC
Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.867
queF
NADPH-dependent 7-cyano-7-deazaguanine reductase (modular protein); Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
  
  
 0.779
NIDE4039
Homologs of previously reported genes of unknown function.
       0.652
NIDE4040
Putative Fe-S oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
    0.566
hisI
Fused Phosphoribosyl-AMP cyclohydrolase and Phosphoribosyl-ATP diphosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the PRA-CH family.
     
 0.482
cysS
Cysteinyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.461
NIDE4037
Membrane protein of unknown function; No homology to any previously reported sequences.
   
   0.434
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.