close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIDE4168Putative Glutathione-regulated potassium-efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (674 aa)    
Predicted Functional Partners:
NIDE3799
Putative NAD(P)H dehydrogenase (quinone); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.935
flgF
Flagellar basal-body rod protein FlgF; Function of homologous gene experimentally demonstrated in an other organism; structure.
    
   0.831
flgG
Flagellar basal-body rod protein FlgG; Function of homologous gene experimentally demonstrated in an other organism; structure.
    
   0.831
ybaL
Uncharacterised monovalent cation:proton antiporter, CPA2 family; Function of strongly homologous gene; transporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
 
  
0.652
gltB
Glutamate synthase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 0.625
NIDE2560
Protein of unknown function; No homology to any previously reported sequences.
  
  
 0.595
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.584
NIDE1587
Protein of unknown function, putative Sensory histidine kinase with methyltransferase region; No homology to any previously reported sequences; 11369279, 11489844, 15009198, 16176121, 16622408, 18076326, 7699720, 9301332, 9382818.
 
   
 0.576
NIDE2443
Conserved membrane protein of unknown function DUF1504; Homologs of previously reported genes of unknown function.
     
 0.533
NIDE0052
Metallo-beta-lactamase superfamily hydrolase; Function of strongly homologous gene; enzyme.
 
  
 0.529
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.