STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIDE4295Exported protein of unknown function, putative Staphylococcal nuclease; No homology to any previously reported sequences; 17172296, 1896431, 8045422, 9041650. (209 aa)    
Predicted Functional Partners:
rnpA
Putative Ribonuclease P, protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
   
    0.733
NIDE4294
Protein of unknown function; No homology to any previously reported sequences.
       0.561
NIDE1759
Homologs of previously reported genes of unknown function.
 
     0.558
NIDE3206
Exported protein of unknown function, putative Tyrosinase; No homology to any previously reported sequences; 1901488, 8939424, 9846879.
  
     0.509
NIDE1129
Homologs of previously reported genes of unknown function; 9724625.
 
     0.506
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.488
phd
Antitoxin of toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system.
       0.477
stbE
Addiction module toxin; Function of strongly homologous gene; cell process.
       0.477
NIDE1438
Homologs of previously reported genes of unknown function.
   
    0.469
NIDE1479
Conserved protein of unknown function, putative sterol desaturase; Homologs of previously reported genes of unknown function.
   
    0.469
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.