node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NIDE4326 | dtd | NIDE4326 | NIDE4327 | Homologs of previously reported genes of unknown function. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.537 |
NIDE4326 | mviN-2 | NIDE4326 | NIDE4329 | Homologs of previously reported genes of unknown function. | Virulence factor MviN homolog; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.471 |
NIDE4326 | ogt | NIDE4326 | NIDE4328 | Homologs of previously reported genes of unknown function. | Methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.472 |
NIDE4330 | NIDE4331 | NIDE4330 | NIDE4331 | Homologs of previously reported genes of unknown function. | Conserved membrane protein of unknown function DUF477; Homologs of previously reported genes of unknown function. | 0.958 |
NIDE4330 | NIDE4332 | NIDE4330 | NIDE4332 | Homologs of previously reported genes of unknown function. | Conserved exported protein of unknown function, LemA-like; Homologs of previously reported genes of unknown function. | 0.888 |
NIDE4330 | dtd | NIDE4330 | NIDE4327 | Homologs of previously reported genes of unknown function. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.544 |
NIDE4330 | mviN-2 | NIDE4330 | NIDE4329 | Homologs of previously reported genes of unknown function. | Virulence factor MviN homolog; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.621 |
NIDE4330 | ogt | NIDE4330 | NIDE4328 | Homologs of previously reported genes of unknown function. | Methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.621 |
NIDE4331 | NIDE4330 | NIDE4331 | NIDE4330 | Conserved membrane protein of unknown function DUF477; Homologs of previously reported genes of unknown function. | Homologs of previously reported genes of unknown function. | 0.958 |
NIDE4331 | NIDE4332 | NIDE4331 | NIDE4332 | Conserved membrane protein of unknown function DUF477; Homologs of previously reported genes of unknown function. | Conserved exported protein of unknown function, LemA-like; Homologs of previously reported genes of unknown function. | 0.946 |
NIDE4331 | dtd | NIDE4331 | NIDE4327 | Conserved membrane protein of unknown function DUF477; Homologs of previously reported genes of unknown function. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.544 |
NIDE4331 | mviN-2 | NIDE4331 | NIDE4329 | Conserved membrane protein of unknown function DUF477; Homologs of previously reported genes of unknown function. | Virulence factor MviN homolog; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.621 |
NIDE4331 | ogt | NIDE4331 | NIDE4328 | Conserved membrane protein of unknown function DUF477; Homologs of previously reported genes of unknown function. | Methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.621 |
NIDE4332 | NIDE4330 | NIDE4332 | NIDE4330 | Conserved exported protein of unknown function, LemA-like; Homologs of previously reported genes of unknown function. | Homologs of previously reported genes of unknown function. | 0.888 |
NIDE4332 | NIDE4331 | NIDE4332 | NIDE4331 | Conserved exported protein of unknown function, LemA-like; Homologs of previously reported genes of unknown function. | Conserved membrane protein of unknown function DUF477; Homologs of previously reported genes of unknown function. | 0.946 |
NIDE4332 | dtd | NIDE4332 | NIDE4327 | Conserved exported protein of unknown function, LemA-like; Homologs of previously reported genes of unknown function. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.481 |
NIDE4332 | mviN-2 | NIDE4332 | NIDE4329 | Conserved exported protein of unknown function, LemA-like; Homologs of previously reported genes of unknown function. | Virulence factor MviN homolog; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.549 |
NIDE4332 | ogt | NIDE4332 | NIDE4328 | Conserved exported protein of unknown function, LemA-like; Homologs of previously reported genes of unknown function. | Methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.534 |
ada | alkA | NIDE3537 | NIDE0051 | Methylated-DNA-[protein]-cysteine S-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | DNA-3-methyladenine glycosylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.585 |
ada | lpxB | NIDE3537 | NIDE3037 | Methylated-DNA-[protein]-cysteine S-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Lipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.525 |