| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIDE1916 | NIDE3847 | NIDE1916 | NIDE3847 | Homologs of previously reported genes of unknown function. | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.407 |
| NIDE1916 | dnaN | NIDE1916 | NIDE0002 | Homologs of previously reported genes of unknown function. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.977 |
| NIDE1916 | mutY | NIDE1916 | NIDE1914 | Homologs of previously reported genes of unknown function. | A/G-specific adenine glycosylase (fragment); Function of strongly homologous gene; enzyme. | 0.701 |
| NIDE1916 | polA | NIDE1916 | NIDE4158 | Homologs of previously reported genes of unknown function. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.978 |
| NIDE1916 | xthA | NIDE1916 | NIDE4335 | Homologs of previously reported genes of unknown function. | Exodeoxyribonuclease III; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.713 |
| NIDE3847 | NIDE1916 | NIDE3847 | NIDE1916 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Homologs of previously reported genes of unknown function. | 0.407 |
| NIDE3847 | dnaN | NIDE3847 | NIDE0002 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.614 |
| NIDE3847 | mutY | NIDE3847 | NIDE1914 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | A/G-specific adenine glycosylase (fragment); Function of strongly homologous gene; enzyme. | 0.785 |
| NIDE3847 | nth | NIDE3847 | NIDE2460 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.826 |
| NIDE3847 | nth-2 | NIDE3847 | NIDE4162 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.826 |
| NIDE3847 | polA | NIDE3847 | NIDE4158 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.890 |
| NIDE3847 | xthA | NIDE3847 | NIDE4335 | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Exodeoxyribonuclease III; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.702 |
| alkA | polA | NIDE0051 | NIDE4158 | DNA-3-methyladenine glycosylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.572 |
| alkA | xthA | NIDE0051 | NIDE4335 | DNA-3-methyladenine glycosylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Exodeoxyribonuclease III; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.771 |
| dnaN | NIDE1916 | NIDE0002 | NIDE1916 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Homologs of previously reported genes of unknown function. | 0.977 |
| dnaN | NIDE3847 | NIDE0002 | NIDE3847 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative DNA-directed DNA polymerase, family X, modulated with phosphoesterase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.614 |
| dnaN | mutY | NIDE0002 | NIDE1914 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | A/G-specific adenine glycosylase (fragment); Function of strongly homologous gene; enzyme. | 0.843 |
| dnaN | polA | NIDE0002 | NIDE4158 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.996 |
| dnaN | ung | NIDE0002 | NIDE1448 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.865 |
| dnaN | xthA | NIDE0002 | NIDE4335 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Exodeoxyribonuclease III; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.818 |