ALH80505.1 protein (Sphingopyxis macrogoltabida)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

ALH80505.1

PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)

Predicted Functional Partners:

ALH79807.1

0.971

ALH82261.1

0.969

ALH81029.1

0.961

ALH79946.1

0.953

ALH79693.1

0.952

ALH79274.1

0.949

ALH79364.1

0.949

ALH79985.1

0.949

ALH81016.1

0.946

ALH81160.1

0.944

Your Current Organism:

Sphingopyxis macrogoltabida

NCBI taxonomy Id: 33050
Other names: ATCC 51380, CIP 104196, DSM 8826, IFO 15033, JCM 10192, LMG 17324, LMG:17324, NBRC 15033, S. macrogoltabida, Sphingomonas macrogolitabida, Sphingomonas macrogoltabidus, strain 203

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALH79274.1	ALH79364.1	AN936_02460	AN936_02970	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
ALH79274.1	ALH79693.1	AN936_02460	AN936_04750	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.939
ALH79274.1	ALH79807.1	AN936_02460	AN936_05340	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ALH79274.1	ALH79946.1	AN936_02460	AN936_06070	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Start codon location was manually corrected by using GenomeMatcher.	0.979
ALH79274.1	ALH79985.1	AN936_02460	AN936_06270	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.659
ALH79274.1	ALH80505.1	AN936_02460	AN936_09020	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.949
ALH79274.1	ALH81016.1	AN936_02460	AN936_11755	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Start codon location was manually corrected by using GenomeMatcher.	0.977
ALH79274.1	ALH81029.1	AN936_02460	AN936_11825	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.982
ALH79274.1	ALH81160.1	AN936_02460	AN936_12515	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
ALH79274.1	ALH82261.1	AN936_02460	AN936_18465	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ALH79364.1	ALH79274.1	AN936_02970	AN936_02460	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
ALH79364.1	ALH79693.1	AN936_02970	AN936_04750	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
ALH79364.1	ALH79807.1	AN936_02970	AN936_05340	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ALH79364.1	ALH79946.1	AN936_02970	AN936_06070	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Start codon location was manually corrected by using GenomeMatcher.	0.993
ALH79364.1	ALH79985.1	AN936_02970	AN936_06270	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
ALH79364.1	ALH80505.1	AN936_02970	AN936_09020	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.949
ALH79364.1	ALH81016.1	AN936_02970	AN936_11755	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Start codon location was manually corrected by using GenomeMatcher.	0.993
ALH79364.1	ALH81029.1	AN936_02970	AN936_11825	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ALH79364.1	ALH81160.1	AN936_02970	AN936_12515	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
ALH79364.1	ALH82261.1	AN936_02970	AN936_18465	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003756

Protein disulfide isomerase activity

4 of 4

3.32

4.69

3.06e-09

GO:0015035

Protein-disulfide reductase activity

4 of 19

2.64

3.66

1.29e-07

GO:0140096

Catalytic activity, acting on a protein

7 of 1397

1.02

0.97

0.00016

GO:0003824

Catalytic activity

9 of 5325

0.55

0.39

0.0114

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005788

Endoplasmic reticulum lumen

2 of 22

2.28

0.89

0.0232

GO:0005737

Cytoplasm

10 of 5892

0.55

0.4

0.0084

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:29562928

(2018) Trees, fungi and bacteria: tripartite metatranscriptomics of a root microbiome responding to soil contamination.

2 of 15

2.45

1.74

0.00059

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11481

Thioredoxin domain, and Peroxiredoxin-5-like

4 of 11

2.88

3.81

9.09e-08

CL:11484

Protein repair, and Peroxiredoxin-5-like

3 of 6

3.02

2.89

5.37e-06

CL:11272

Mixed, incl. Protein disulfide isomerase activity, and Protein folding in endoplasmic reticulum

3 of 11

2.76

2.59

1.74e-05

CL:23485

Ammonia transport, and Permease family

2 of 5

2.92

1.56

0.0015

CL:11059

Protein folding, and Conjugation with cellular fusion

4 of 188

1.65

1.46

0.00058

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

7 of 268

1.74

3.22

1.50e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3299685

Detoxification of Reactive Oxygen Species

3 of 28

2.35

1.84

0.00034

MAP-5676934

Protein repair

2 of 4

3.02

1.56

0.0015

MAP-844456

The NLRP3 inflammasome

2 of 11

2.58

1.32

0.0038

MAP-622312

Inflammasomes

2 of 11

2.58

1.32

0.0038

MAP-9711123

Cellular response to chemical stress

3 of 86

1.86

1.28

0.0028

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005783

Endoplasmic reticulum

4 of 298

1.45

1.03

0.0045

GOCC:0005737

Cytoplasm

9 of 3800

0.7

0.52

0.0037

GOCC:0005622

Intracellular

11 of 8487

0.43

0.34

0.0058

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0676

Redox-active center

5 of 9

3.07

6.16

4.11e-12

KW-1015

Disulfide bond

5 of 62

2.23

3.87

9.81e-09

KW-0413

Isomerase

3 of 55

2.06

1.87

0.00020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00085

Thioredoxin

6 of 7

3.25

7.81

4.34e-15

PF14595

Thioredoxin

2 of 2

3.32

1.75

0.00071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013766

Thioredoxin domain

8 of 17

2.99

9.74

2.91e-19

IPR036249

Thioredoxin-like superfamily

9 of 81

2.37

7.62

1.23e-17

IPR017937

Thioredoxin, conserved site

5 of 6

3.24

6.22

4.21e-12

IPR005788

Disulphide isomerase

2 of 2

3.32

1.67

0.00099

IPR005746

Thioredoxin

2 of 2

3.32

1.67

0.00099

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