| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SB4_00480 | SB4_02220 | SB4_00480 | SB4_02220 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.979 |
| SB4_00480 | SB4_05585 | SB4_00480 | SB4_05585 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.794 |
| SB4_00480 | SB4_17105 | SB4_00480 | SB4_17105 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.421 |
| SB4_00480 | glnA | SB4_00480 | SB4_02215 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.536 |
| SB4_00480 | glnD | SB4_00480 | SB4_12200 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.646 |
| SB4_01830 | SB4_02220 | SB4_01830 | SB4_02220 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.579 |
| SB4_02220 | SB4_00480 | SB4_02220 | SB4_00480 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.979 |
| SB4_02220 | SB4_01830 | SB4_02220 | SB4_01830 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.579 |
| SB4_02220 | SB4_02410 | SB4_02220 | SB4_02410 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nitrate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.751 |
| SB4_02220 | SB4_05180 | SB4_02220 | SB4_05180 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tetratricopeptide repeat family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.579 |
| SB4_02220 | SB4_05585 | SB4_02220 | SB4_05585 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
| SB4_02220 | SB4_10370 | SB4_02220 | SB4_10370 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.579 |
| SB4_02220 | SB4_17105 | SB4_02220 | SB4_17105 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.678 |
| SB4_02220 | argB | SB4_02220 | SB4_13745 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | 0.828 |
| SB4_02220 | glnA | SB4_02220 | SB4_02215 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.938 |
| SB4_02220 | glnD | SB4_02220 | SB4_12200 | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.982 |
| SB4_02410 | SB4_02220 | SB4_02410 | SB4_02220 | Nitrate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.751 |
| SB4_02410 | SB4_17105 | SB4_02410 | SB4_17105 | Nitrate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.435 |
| SB4_05180 | SB4_02220 | SB4_05180 | SB4_02220 | Tetratricopeptide repeat family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.579 |
| SB4_05585 | SB4_00480 | SB4_05585 | SB4_00480 | Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.794 |
