STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SB4_06335DNA repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)    
Predicted Functional Partners:
SB4_11345
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.982
lexA
LexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
 0.883
SB4_06340
2OG-Fe(II) oxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.773
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.763
SB4_04275
ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AAA ATPase family.
     
 0.748
SB4_18215
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 0.669
SB4_18295
DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.669
SB4_04605
Protein ImuA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.599
SB4_09620
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.599
SB4_09685
Cell division protein FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family.
   
 
 0.593
Your Current Organism:
Sphingomonas sanguinis
NCBI taxonomy Id: 33051
Other names: 13937T, ATCC 51382, CIP 104197, DSM 13885, GIFU 2397, GIFU:2397, HAMBI 2010, IFO 13937, JCM 7514, LMG 17325, LMG:17325, NBRC 13937, S. sanguinis, Sphingomonas sanguis, strain 13937
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.