node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SB4_04045 | SB4_05680 | SB4_04045 | SB4_05680 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.717 |
SB4_04045 | hisA | SB4_04045 | SB4_07970 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.941 |
SB4_04045 | hisB | SB4_04045 | SB4_07960 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.947 |
SB4_04045 | hisC | SB4_04045 | SB4_08110 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.717 |
SB4_04045 | hisD | SB4_04045 | SB4_14725 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.946 |
SB4_04045 | hisE | SB4_04045 | SB4_07980 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
SB4_04045 | hisF | SB4_04045 | SB4_07975 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.975 |
SB4_04045 | hisG | SB4_04045 | SB4_14730 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
SB4_04045 | hisH | SB4_04045 | SB4_07965 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.911 |
SB4_04045 | hisI | SB4_04045 | SB4_01660 | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.966 |
SB4_05680 | SB4_04045 | SB4_05680 | SB4_04045 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | tRNA synthetase class II; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.717 |
SB4_05680 | hisA | SB4_05680 | SB4_07970 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.866 |
SB4_05680 | hisB | SB4_05680 | SB4_07960 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.991 |
SB4_05680 | hisC | SB4_05680 | SB4_08110 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.900 |
SB4_05680 | hisD | SB4_05680 | SB4_14725 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.976 |
SB4_05680 | hisE | SB4_05680 | SB4_07980 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.827 |
SB4_05680 | hisF | SB4_05680 | SB4_07975 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.966 |
SB4_05680 | hisG | SB4_05680 | SB4_14730 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.888 |
SB4_05680 | hisH | SB4_05680 | SB4_07965 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.977 |
SB4_05680 | hisI | SB4_05680 | SB4_01660 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.940 |