Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SB4_17845Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)    
Predicted Functional Partners:
SB4_09135
DNA topoisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
   0.708
SB4_02060
DNA methylase N-4; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.707
SB4_13015
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.650
SB4_08185
Ankyrin; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.622
SB4_17850
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.608
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.602
parE
DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
    
 
 0.602
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
    
   0.478
SB4_18210
Histone deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.445
SB4_18275
Histone deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.445
Your Current Organism:
Sphingomonas sanguinis
NCBI taxonomy Id: 33051
Other names: 13937T, ATCC 51382, CIP 104197, DSM 13885, GIFU 2397, GIFU:2397, HAMBI 2010, IFO 13937, JCM 7514, LMG 17325, LMG:17325, NBRC 13937, S. sanguinis, Sphingomonas sanguis, strain 13937
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