STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pbgPorphobilinogen deaminase. (296 aa)    
Predicted Functional Partners:
alaD
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.999
Saci_0781
Conserved protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 0.998
gluTR
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.991
hemL
Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
  
 0.988
Saci_0914
uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
  
 0.965
uroM
uroporphyrin-III C-methyltransferase; Similar to sp:P36150.
  
 0.951
Saci_0776
Conserved Archaeal protein.
 
  
 0.939
Saci_0394
Methyltransferase.
    
 0.785
fen
XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...]
  
  
 0.756
cobQ
Cobyrinic acid A,C-diamide synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
     
 0.688
Your Current Organism:
Sulfolobus acidocaldarius DSM 639
NCBI taxonomy Id: 330779
Other names: S. acidocaldarius DSM 639, Sulfolobus acidocaldarius ATCC 33909, Sulfolobus acidocaldarius NCIB 11770
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.