STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rib75-amino-6-(5-phosphoribosylamino)uracil reductase. (214 aa)    
Predicted Functional Partners:
Saci_0822
3,4-dihydroxy-2-butanone 4-phosphate synthase.
 
 
 0.968
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.958
Saci_2165
Glycerophosphoryl diester phosphodiesterase.
 
   
 0.711
Saci_0932
Conserved Archaeal protein; Similar to gi:15920764.
     
 0.673
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
  
 0.626
pyrF
Orotidine 5'-phosphate decarboxylase.
 
  
 0.580
actP
Truncated copper-transporting P-type ATPase.
  
  
 0.568
folE
GTP cyclohydrolase I.
     
 0.565
Saci_0818
Conserved Archaeal protein.
 
   
 0.564
uppS
Undecaprenyl pyrophosphate synthetase; Generates tritrans,heptacis-undecaprenyl diphosphate from isopentenyl pyrophosphate (IPP) and geranylgeranyl diphosphate. It is probably the precursor of glycosyl carrier lipids; Belongs to the UPP synthase family.
  
  
 0.556
Your Current Organism:
Sulfolobus acidocaldarius DSM 639
NCBI taxonomy Id: 330779
Other names: S. acidocaldarius DSM 639, Sulfolobus acidocaldarius ATCC 33909, Sulfolobus acidocaldarius NCIB 11770
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