B0A49_12721 protein (Cryomyces minteri) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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B0A49_12721

Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family. (365 aa)

Predicted Functional Partners:

B0A49_09100

0.615

B0A49_04942

0.615

B0A49_11829

0.594

B0A49_06642

0.594

B0A49_07683

0.567

B0A49_03773

0.520

B0A49_13191

0.509

B0A49_00069

0.432

B0A49_13109

0.404

Your Current Organism:

Cryomyces minteri

NCBI taxonomy Id: 331657
Other names: C. minteri, CBS 116302, CBS 116302 (ex-type); CCFEE 5187, CCFEE 5187

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A49_00069	B0A49_03773	A0A4U0Y1U9	A0A4V5NH23	Putative Ras-related protein Rab7.	DIOX_N domain-containing protein.	0.432
B0A49_00069	B0A49_12721	A0A4U0Y1U9	A0A4U0WAZ7	Putative Ras-related protein Rab7.	Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.432
B0A49_00069	B0A49_13109	A0A4U0Y1U9	A0A4U0VI92	Putative Ras-related protein Rab7.	DIOX_N domain-containing protein.	0.432
B0A49_00069	B0A49_13191	A0A4U0Y1U9	A0A4U0VN14	Putative Ras-related protein Rab7.	Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.432
B0A49_03773	B0A49_00069	A0A4V5NH23	A0A4U0Y1U9	DIOX_N domain-containing protein.	Putative Ras-related protein Rab7.	0.432
B0A49_03773	B0A49_04942	A0A4V5NH23	A0A4U0XAD7	DIOX_N domain-containing protein.	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	0.615
B0A49_03773	B0A49_06642	A0A4V5NH23	A0A4V5NFB5	DIOX_N domain-containing protein.	Uncharacterized protein.	0.594
B0A49_03773	B0A49_07683	A0A4V5NH23	A0A4U0WUB8	DIOX_N domain-containing protein.	PKS_KS domain-containing protein.	0.567
B0A49_03773	B0A49_09100	A0A4V5NH23	A0A4U0X2P5	DIOX_N domain-containing protein.	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	0.615
B0A49_03773	B0A49_11829	A0A4V5NH23	A0A4U0VV11	DIOX_N domain-containing protein.	Uncharacterized protein.	0.594
B0A49_03773	B0A49_12721	A0A4V5NH23	A0A4U0WAZ7	DIOX_N domain-containing protein.	Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.520
B0A49_04942	B0A49_03773	A0A4U0XAD7	A0A4V5NH23	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	DIOX_N domain-containing protein.	0.615
B0A49_04942	B0A49_06642	A0A4U0XAD7	A0A4V5NFB5	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	Uncharacterized protein.	0.992
B0A49_04942	B0A49_11829	A0A4U0XAD7	A0A4U0VV11	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	Uncharacterized protein.	0.984
B0A49_04942	B0A49_12721	A0A4U0XAD7	A0A4U0WAZ7	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.615
B0A49_04942	B0A49_13109	A0A4U0XAD7	A0A4U0VI92	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	DIOX_N domain-containing protein.	0.615
B0A49_04942	B0A49_13191	A0A4U0XAD7	A0A4U0VN14	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.615
B0A49_06642	B0A49_03773	A0A4V5NFB5	A0A4V5NH23	Uncharacterized protein.	DIOX_N domain-containing protein.	0.594
B0A49_06642	B0A49_04942	A0A4V5NFB5	A0A4U0XAD7	Uncharacterized protein.	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	0.992
B0A49_06642	B0A49_09100	A0A4V5NFB5	A0A4U0X2P5	Uncharacterized protein.	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	0.992

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.871

expected number of edges:

11

PPI enrichment p-value:

1.92e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007154

Cell communication

11 of 1248

1.21

1.82

2.40e-10

GO:0006468

Protein phosphorylation

6 of 426

1.41

1.63

2.20e-05

GO:0048312

Intracellular distribution of mitochondria

2 of 4

2.96

1.63

0.0011

GO:1900242

Regulation of synaptic vesicle endocytosis

2 of 5

2.87

1.57

0.0014

GO:0007165

Signal transduction

9 of 1111

1.17

1.5

2.71e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001784

Phosphotyrosine residue binding

3 of 20

2.44

2.2

7.26e-05

GO:0005102

Signaling receptor binding

5 of 184

1.7

1.87

5.16e-05

GO:0030971

Receptor tyrosine kinase binding

2 of 7

2.72

1.72

0.00072

GO:0004672

Protein kinase activity

6 of 411

1.43

1.57

5.16e-05

GO:0004713

Protein tyrosine kinase activity

3 of 97

1.75

1.41

0.0011

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043195

Terminal bouton

2 of 23

2.2

0.95

0.0174

GO:0044297

Cell body

2 of 26

2.15

0.94

0.0174

GO:0031234

Extrinsic component of cytoplasmic side of plasma membrane

2 of 37

2.0

0.93

0.0174

GO:0005925

Focal adhesion

2 of 34

2.03

0.93

0.0174

GO:0030425

Dendrite

3 of 108

1.71

0.88

0.0174

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:257

Mixed, incl. RHO GTPase cycle, and Non-membrane spanning protein tyrosine kinase activity

5 of 127

1.86

2.26

1.12e-05

CL:532

Interleukin-15 signaling, and Signalling to RAS

2 of 5

2.87

1.21

0.0064

CL:450

MAP2K and MAPK activation

2 of 6

2.79

1.21

0.0064

CL:344

Intracellular distribution of mitochondria, and Immunoglobulin V-set domain

2 of 5

2.87

1.21

0.0064

CL:1715

Mixed, incl. Localization of the PINCH-ILK-PARVIN complex to focal adhesions, and Dedicator of cytokinesis, C-terminal, lobe A

2 of 5

2.87

1.21

0.0064

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04068

FoxO signaling pathway

3 of 100

1.74

1.22

0.0031

map04150

mTOR signaling pathway

3 of 128

1.63

1.17

0.0032

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-187687

Signalling to ERKs

4 of 8

2.96

4.1

2.80e-08

MAP-167044

Signalling to RAS

3 of 4

3.14

3.27

1.15e-06

MAP-187037

Signaling by NTRK1 (TRKA)

4 of 35

2.32

3.03

1.15e-06

MAP-166520

Signaling by NTRKs

4 of 42

2.24

2.93

1.52e-06

MAP-9006934

Signaling by Receptor Tyrosine Kinases

6 of 220

1.7

2.54

3.22e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

3 of 18

2.49

2.04

0.00016

GOCC:0032473

Cytoplasmic side of mitochondrial outer membrane

2 of 2

3.26

1.81

0.00055

GOCC:0005901

Caveola

2 of 10

2.56

1.28

0.0045

GOCC:0005925

Focal adhesion

2 of 16

2.36

1.17

0.0070

GOCC:0110165

Cellular anatomical entity

11 of 8823

0.36

0.28

0.0138

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0727

SH2 domain

2 of 32

2.06

1.03

0.0115

KW-0418

Kinase

3 of 123

1.65

1.0

0.0087

KW-0547

Nucleotide-binding

4 of 462

1.2

0.8

0.0093

KW-0723

Serine/threonine-protein kinase

2 of 73

1.7

0.74

0.0355

KW-0067

ATP-binding

3 of 341

1.21

0.63

0.0355

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036860

SH2 domain superfamily

4 of 36

2.31

2.53

1.32e-05

IPR017441

Protein kinase, ATP binding site

4 of 90

1.91

1.81

0.00019

IPR000719

Protein kinase domain

5 of 246

1.57

1.56

0.00019

IPR011009

Protein kinase-like domain superfamily

5 of 287

1.5

0.00020

IPR001245

Serine-threonine/tyrosine-protein kinase, catalytic domain

3 of 56

1.99

1.35

0.0023

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

3 of 32

2.24

1.84

0.00031

SM00219

Tyrosine kinase, catalytic domain

2 of 6

2.79

1.55

0.0015

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